Depression affects as many as 18 million Americans every year, not to mention their friends and family members. Psychiatric drugs can perform minor miracles, but controversial new research suggests for some facing depression, medication may be no more effective than doing nothing. As ideastream - in collaboration with the Plain Dealer - begins a week of comprehensive coverage of depression, we'll spend the hour Monday morning explaining the differences between clinical depression and just "feeling blue," we'll delve into how medications work, side effects and other treatment options.

Dr. Keming Gao Assistant Professor of Psychiatry, Case Western Reserve University School of Medicine; Clinical Director of the Mood Disorders Program in the Department of Psychiatry at University Hospitals Case Medical Center

Dr. Toni Johnson Chair, Department of Psychiatry, Metrohealth Systems